A rapid and effective catalytic pathway for the synthesis of thiazine derivatives employing Zno nanoparticles

Abstract

A sustainable approach has been successfully developed for the synthesis of thiazine derivatives, utilizing an efficient catalytic method. ZnO nanoparticles have demonstrated remarkable catalytic prowess, offering cost-effectiveness, heightened yields, and reduced reaction durations. This method presents a direct, environmentally conscious, gentle, and easily applicable pathway to producing a range of thiazine compounds. Following the completion of the reaction, the catalyst can be reused without a discernible decrease in its effectiveness, thereby establishing this process as both cost-efficient and eco-friendly. The structural authenticity of all synthesized compounds (3a-j) has been proved through ¹H-NMR, elemental analysis, FT-IR, ¹³C NMR, and mass spectral data. This innovative and green approach toward synthesizing the thiazine derivatives emphasizes a perspective by controlling the catalytic potential of ZnO nanoparticles. Its noteworthy advantages lie in its ability to enhance shortens reaction times, yield, and reduce costs, while also promoting environmental sustainability. The ease and simplicity of implementation further highlight its potential as a viable method in the production of thiazine compounds. The recycling capability of the catalyst ensures sustained cost-effectiveness by reducing the ecological impact of the overall process thus providing a significant advantage to the synthetic pathway. This eco-friendly method not only contributes to a more sustainable chemical synthesis approach but also offers a promising pathway for further developments in the production of thiazine derivatives, proving its efficacy through both in its verification of synthesized compound structures and environmental considerations. The antimicrobial screening as antibacterial and antifungal were tested against the three pathogenic bacteria and two fungal pathogens. The antimicrobial properties of the compounds range from strong to moderate.