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Abstract
20 adult female rats Rattus ratus were exposed with 5 ppm of parathion (organophosphorus compound) for 60 days and their vaginal smears were examined to observe the estrous cycle.It is very axiomatic from the results that estrous cycle has been disrupted in experimental animal treated with parathion, which has been observed by direct fall in number of estrous cycles in treated animal as compared to control.
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References
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- Soratur, S.M. and Kaliwal, B.B. 1999 Effect of methyl parathion formulation on estrous cycle and reproductive performance in albino rats. Indian J Expt Biol 37,176-8.
- Welch, R.M., Lerin, W. and Conney A.H. 1969 Estrogenic action of DDT and its analogs. Toxicol Appl Pharmacol 14, 358-67. DOI: https://doi.org/10.1016/0041-008X(69)90117-3
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References
Baligar, P.N. and Kaliwar ,B.B. 2001 Induction of gonadal toxicity to female rats after chronic exposure to mancozeb. Ind Health 39,235-43. DOI: https://doi.org/10.2486/indhealth.39.235
Budreau, C.H.and Singh, R.P. 1973 Effect of fenthion and dimethoate on reproduction in the mouse. Toxicol Appl Phramacol 26,29-38. DOI: https://doi.org/10.1016/0041-008X(73)90082-3
Cooper, R.L., Goldman, J.M., Vandenbergh ,J.G. 1993 Monitoring of the estrous cycle in the laboratory rodent vaginal lavage.In: Methods in toxicology female reproductive toxicol- ogy, eds. by Heindel, J.J. Chapin, Re.vol 3 B, 57-8 Academic Press, San Diego.
Donald, W. and Ronald, H.K. 1997 Infertility in male pesticide workers. Lancet 2, 1259-61 Gupta, R.D, Kadel, W.L. 1989 Concerted role of carboxylesterases in the potentiation of carbofuran toxicity by iso-OMPA Pretreatment. J Toxicol Environ Health 26, 447-57. DOI: https://doi.org/10.1080/15287398909531268
Hirshifield ,A.N. 1991 Development of follicles in the mammalian ovary. Int. Rev Cytol 124, 43-100. Hoyer, P.B., Sipes, I.G. 1996 Assessment of follicle destruction in chemical induced ovarian toxic-ity. Ann Rev Pharmacol Toxicol 35, 307-31. DOI: https://doi.org/10.1146/annurev.pa.36.040196.001515
Jadaramkunti ,U.C. and Kaliwal B.B. 1999 Effect of dicofol formulation on estrous cycle and follicular dynamics in albino rats. J. Bsic. Clinical Physiol. Pharmacol. 10,305-19. DOI: https://doi.org/10.1515/JBCPP.1999.10.4.305
Janardhan, A., Bhaskar Rao, A.and Sesodia ,A. 1986 Species variation in acute toxicity or monocrotophos and benzimididazole carbamate.Ind J Exp Biol 18,102-3.
Lener L.J. 1969 The biology of non-streoidal antifertility, In: Contraception, chemical control of fertilitu. ed. by Lednicer D, Marcel Derker Inc, New York.
Prakash, N. ,Baligar, B. K, 2002 Reproductive Toxicity of Carbofuran to the female Mice: Effect on estrous cycle and follicles, Industrial health, 345-352. DOI: https://doi.org/10.2486/indhealth.40.345
Soratur, S.M. and Kaliwal, B.B. 1999 Effect of methyl parathion formulation on estrous cycle and reproductive performance in albino rats. Indian J Expt Biol 37,176-8.
Welch, R.M., Lerin, W. and Conney A.H. 1969 Estrogenic action of DDT and its analogs. Toxicol Appl Pharmacol 14, 358-67. DOI: https://doi.org/10.1016/0041-008X(69)90117-3
Wuestar, C.F. Jr, and Wringnaate, D.B. 1968 DDT residues and declining reproduction in Bermuda petrel. Science, 159,978-81. DOI: https://doi.org/10.1126/science.159.3818.979