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Abstract
The hepatoprotective activity of methanolic rhizome extract of Curculigo orchioides (MECO) were evaluated against Thioacetamide-induced hepatic damage in rats. The MECO at dose of 100, 200 and 400 mg/kg were administered orally once daily for 21 days and simultaneously administered TAA 100 mg/kg b.w. s.c. 1 h after the respective assigned treatments every 72 h. Serum enzymatic levels of serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (ALP) and total bilirubin were estimated along with estimation of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in liver tissues.
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References
- Ala-Kokko, L., Stenback, F. & Ryhanen, L. 1987. Preventive effect of malotilate on carbon tetrachloride induced liver damage and collagen accumulation in the rat.Biochemical journal, 246: 503-509.
- Anonymous. Ayurvedic pharmacopoeia of India 2004. In: Ayush, editor. 1st ed. New Delhi: Ayush.
- Asif, M. 2012. A review on phytochemical and ethnopharmacological activities of curculigo orchioides. Mahidol university journal of pharmaceutical sciences, 39(3.4): 1-10.
- Bafna, A. R., Mishra, S. H. 2006. Immuno stimulatory effect of methanol extract of Curculigo orchioides on immuno suppressed mice. Journal of Ethno pharmacology, 104: 1-4.
- Cao, D. P., Zheng, Y. N., Qin, L. P., Han, T., Zhang, H., Rahman, K. and Zhang, Q. Y. 2008. Curculigo orchioides, a traditional Chinese medicinal plant, prevents bone loss in ovariectomized rats. Maturitas, 59: 373-380.
- Chauhan, N. S., Rao, C. V. and Dixit, V. K. 2007. Effect of Curculigo orchioides rhizomes on sexual behaviour of male rats. Fitoterapia, 78: 530-534.
- Dall'acqua, S., Shrestha, B. B., Comai, S., Innocenti, G., Gewali, M. B. and Jha, P. K. 2009. Two phenolic glycosides from Curculigo orchioides Gaertn Fitoterapia, 80: 279-282.
- Drotman, R. and Lawhan, G. 1978. Serum enzymes are indications of chemical induced liver damage. Drug Chem Toxicol, 1: 163–171.
- Gupta, M., Achari, B. and Pal, B. C. 2005. Glucosides from Curculigo orchioides Phytochemistry. 66: 659-663.
- Hirayama, C., Morotami, I. and Hiroshige, K. 1979. Quantitative and metabolic changes of hepatic collagens in rats after carbon tetrachloride poisoning. Biochemical journal, 118: 229-302.
- Jiao, L., Cao, D.-P., Qin, L.-P., Han, T., Zhang, Q.-Y., Zhu, Z. and Yan, F. 2009. Antiosteoporotic activity of phenolic compounds from Curculigo orchioides, Phytomedicine, 16: 874-881.
- Jiao, W., Chen, X., Wang, H., Lu, R. and Shao, H. 2013. A new hepatotoxic triterpenoid ketone from Curculigo orchioides. Fitoterapia, 84: 1-5.
- Khare CP., 2007. Indian Medicinal Plants: An Illustrated Dictionary: Springer.
- Lakshmi, V., Pandey, K., Puri, A., Saxena, R. P. and Saxena, K. C. 2003. Immuno stimulant principles from Curculigo orchioides. Journal of Ethnopharmacology, 89: 181-184.
- Low,Teck yew., Maxey and Chung C.M. 2004. A proteomic analysis of thioacetamide induced hapatotoxicity and cirrhosis in rat livers. Proteomics, 4: 3960-3974.
- Misra, H. P. and Fridovich, I. 1972. Role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry, 247: 3170.
- Nourooz-Zadeh, J., Tajaddini-Sarmadi, J., Mccarthy, S., Betteridge, D. J. and Wolff, S. P. 1995. Elevated levels of authentic plasma hydroperoxides in NIDDM. Diabetes, 44: 1054-1058.
- Tian, Z., Yu, W., Liu, H.-B., Zhang, N., Li, X.-B., Zhao, M.-G. and Liu, S.B. 2012. Neuroprotective effects of curculigoside against NMDA-induced neuronal excitoxicity in vitro. Food and Chemical Toxicology, 50: 4010-4015.
- Valls, J., Richard, T., Larronde, F., Leblais, V., Muller, B., Delaunay, J.-C., Monti, J.-P., Ramawat, K. G. and Mérillon, J.-M. 2006. Two new benzylbenzoate glucosides from Curculigo orchioides. Fitoterapia, 77: 416-419.
- Venkatesh, P., Mukherjee, P. K., N, S. K., Nema, N. K., Bandyopadhyay, A., Fukui, H. and Mizuguchi, H. 2009. Mast cell stabilization and antihistaminic potentials of Curculigo orchioides rhizomes. Journal of Ethnopharmacology, 126: 434-436.
- Vijayanarayana, K., Rodrigues, R. S., Chandrashekhar, K. S. and Subrahmanyam, E. V. S. 2007. Evaluation of estrogenic activity of alcoholic extract of rhizomes of Curculigo orchioides. Journal of Ethnopharmacology, 114: 241-245.
- Wang, C.-M., Xu, S.-Y., Lai, S., Geng, D., Huang, J.-M. and Huo, X.Y. 2012. Curculigo orchioides (Xian Mao) modifies the activity and protein expression of CYP3A in normal and Kidney-Yang Deficiency model rats. Journal of Ethnopharmacology, 144: 33-38.
- Wolf, P. L. 1999. Biochemical diagnosis of liver diseases. Indian Journal of Clinical Biochemistry, 14: 59-90.
References
Ala-Kokko, L., Stenback, F. & Ryhanen, L. 1987. Preventive effect of malotilate on carbon tetrachloride induced liver damage and collagen accumulation in the rat.Biochemical journal, 246: 503-509.
Anonymous. Ayurvedic pharmacopoeia of India 2004. In: Ayush, editor. 1st ed. New Delhi: Ayush.
Asif, M. 2012. A review on phytochemical and ethnopharmacological activities of curculigo orchioides. Mahidol university journal of pharmaceutical sciences, 39(3.4): 1-10.
Bafna, A. R., Mishra, S. H. 2006. Immuno stimulatory effect of methanol extract of Curculigo orchioides on immuno suppressed mice. Journal of Ethno pharmacology, 104: 1-4.
Cao, D. P., Zheng, Y. N., Qin, L. P., Han, T., Zhang, H., Rahman, K. and Zhang, Q. Y. 2008. Curculigo orchioides, a traditional Chinese medicinal plant, prevents bone loss in ovariectomized rats. Maturitas, 59: 373-380.
Chauhan, N. S., Rao, C. V. and Dixit, V. K. 2007. Effect of Curculigo orchioides rhizomes on sexual behaviour of male rats. Fitoterapia, 78: 530-534.
Dall'acqua, S., Shrestha, B. B., Comai, S., Innocenti, G., Gewali, M. B. and Jha, P. K. 2009. Two phenolic glycosides from Curculigo orchioides Gaertn Fitoterapia, 80: 279-282.
Drotman, R. and Lawhan, G. 1978. Serum enzymes are indications of chemical induced liver damage. Drug Chem Toxicol, 1: 163–171.
Gupta, M., Achari, B. and Pal, B. C. 2005. Glucosides from Curculigo orchioides Phytochemistry. 66: 659-663.
Hirayama, C., Morotami, I. and Hiroshige, K. 1979. Quantitative and metabolic changes of hepatic collagens in rats after carbon tetrachloride poisoning. Biochemical journal, 118: 229-302.
Jiao, L., Cao, D.-P., Qin, L.-P., Han, T., Zhang, Q.-Y., Zhu, Z. and Yan, F. 2009. Antiosteoporotic activity of phenolic compounds from Curculigo orchioides, Phytomedicine, 16: 874-881.
Jiao, W., Chen, X., Wang, H., Lu, R. and Shao, H. 2013. A new hepatotoxic triterpenoid ketone from Curculigo orchioides. Fitoterapia, 84: 1-5.
Khare CP., 2007. Indian Medicinal Plants: An Illustrated Dictionary: Springer.
Lakshmi, V., Pandey, K., Puri, A., Saxena, R. P. and Saxena, K. C. 2003. Immuno stimulant principles from Curculigo orchioides. Journal of Ethnopharmacology, 89: 181-184.
Low,Teck yew., Maxey and Chung C.M. 2004. A proteomic analysis of thioacetamide induced hapatotoxicity and cirrhosis in rat livers. Proteomics, 4: 3960-3974.
Misra, H. P. and Fridovich, I. 1972. Role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry, 247: 3170.
Nourooz-Zadeh, J., Tajaddini-Sarmadi, J., Mccarthy, S., Betteridge, D. J. and Wolff, S. P. 1995. Elevated levels of authentic plasma hydroperoxides in NIDDM. Diabetes, 44: 1054-1058.
Tian, Z., Yu, W., Liu, H.-B., Zhang, N., Li, X.-B., Zhao, M.-G. and Liu, S.B. 2012. Neuroprotective effects of curculigoside against NMDA-induced neuronal excitoxicity in vitro. Food and Chemical Toxicology, 50: 4010-4015.
Valls, J., Richard, T., Larronde, F., Leblais, V., Muller, B., Delaunay, J.-C., Monti, J.-P., Ramawat, K. G. and Mérillon, J.-M. 2006. Two new benzylbenzoate glucosides from Curculigo orchioides. Fitoterapia, 77: 416-419.
Venkatesh, P., Mukherjee, P. K., N, S. K., Nema, N. K., Bandyopadhyay, A., Fukui, H. and Mizuguchi, H. 2009. Mast cell stabilization and antihistaminic potentials of Curculigo orchioides rhizomes. Journal of Ethnopharmacology, 126: 434-436.
Vijayanarayana, K., Rodrigues, R. S., Chandrashekhar, K. S. and Subrahmanyam, E. V. S. 2007. Evaluation of estrogenic activity of alcoholic extract of rhizomes of Curculigo orchioides. Journal of Ethnopharmacology, 114: 241-245.
Wang, C.-M., Xu, S.-Y., Lai, S., Geng, D., Huang, J.-M. and Huo, X.Y. 2012. Curculigo orchioides (Xian Mao) modifies the activity and protein expression of CYP3A in normal and Kidney-Yang Deficiency model rats. Journal of Ethnopharmacology, 144: 33-38.
Wolf, P. L. 1999. Biochemical diagnosis of liver diseases. Indian Journal of Clinical Biochemistry, 14: 59-90.