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A sustainable approach has been successfully developed for the synthesis of thiazine derivatives, utilizing an efficient catalytic method. ZnO nanoparticles have demonstrated remarkable catalytic prowess, offering cost-effectiveness, heightened yields, and reduced reaction durations. This method presents a direct, environmentally conscious, gentle, and easily applicable pathway to producing a range of thiazine compounds. Following the completion of the reaction, the catalyst can be reused without a discernible decrease in its effectiveness, thereby establishing this process as both cost-efficient and eco-friendly. The structural authenticity of all synthesized compounds (3a-j) has been proved through 1H-NMR, elemental analysis, FT-IR, 13C NMR, and mass spectral data. This innovative and green approach toward synthesizing the thiazine derivatives emphasizes a perspective by controlling the catalytic potential of ZnO nanoparticles. Its noteworthy advantages lie in its ability to enhance shortens reaction times, yield, and reduce costs, while also promoting environmental sustainability. The ease and simplicity of implementation further highlight its potential as a viable method in the production of thiazine compounds. The recycling capability of the catalyst ensures sustained cost-effectiveness by reducing the ecological impact of the overall process thus providing a significant advantage to the synthetic pathway. This eco-friendly method not only contributes to a more sustainable chemical synthesis approach but also offers a promising pathway for further developments in the production of thiazine derivatives, proving its efficacy through both in its verification of synthesized compound structures and environmental considerations. The antimicrobial screening as antibacterial and antifungal were tested against the three pathogenic bacteria and two fungal pathogens. The antimicrobial properties of the compounds range from strong to moderate.


Green chemistry Nanocatalyst Thiazines

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How to Cite
Dhankar, R. P., Bankar , V. V., & Aswale, M. S. (2024). A rapid and effective catalytic pathway for the synthesis of thiazine derivatives employing Zno nanoparticles . Environment Conservation Journal, 25(2), 493–499.


  1. Aswale, M., & Dhankar, R. (2018). Characterization and catalytic activity of ZnO nano catalyst as efficient heterogeneous catalyst for synthesis of substituted 2, 4 dimethyl Quinolines. International journal of basic and applied research, 8,12.
  2. Chidrawar, A. B., Pokalwar, R. U., & Kaminwar, N. S. (2020). An effective multicomponent synthesis of 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b][1, 3] thiazine-3,7-dicarbonitrile. Research Journal of Pharmacy and Technology, 13(6), 2658-2660. DOI:
  3. Fortt, S. M. (1991). Five-membered heterocyclic compounds with two different heteroatoms in the ring. In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds (pp. 3-117). Elsevier. DOI:
  4. Ingarsal, N., Amutha, P., & Nagarajan, S. (2006). Synthesis and antibacterial activities of some 2-amino-4-(1, 1′-biphenyl-4-yl)-6-aryl-6H-1,3-thiazines. Journal of Sulfur Chemistry, 27(5), 455-459. DOI:
  5. Leone, A. J. (2007). Factors related to internal control disclosure: A discussion of Ashbaugh, Collins, and Kinney (2007) and Doyle, Ge, and McVay (2007). Journal of Accounting and Economics, 44(1-2), 224-237. DOI:
  6. Narimani, H. (2022). Research on synthesis of heterocyclic structures using ZnO NPs as catalyst. Journal of Synthetic Chemistry, 1(2), 62-83.
  7. Nematpour, M., Rezaee, E., Jahani, M., & Tabatabai, S. A. (2019). Ultrasound-assisted synthesis of highly functionalized benzo [1, 3] thiazine via Cu-catalyzed intramolecular CH activation reaction from isocyanides, aniline-benzoyl (acetyl) isothiocyanate adduct. Ultrasonics sonochemistry, 50, 1-5. DOI:
  8. Patel, K. H., & Patel, Y. S. (2017). Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives. Orbital: The Electronic Journal of Chemistry, 219-224. DOI:
  9. Shaker, R. M., Ibrahim, Y. R., Abdel-Latif, F. F., & Hamoda, A. (2010). Synthesis of 2, 2-(1,4-Phenylene) bis-3,4-dihydro-2H-1,3-thiazin-4-ones and their Facile Recyclization to 2, 2-(1,4-Phenylene) bis (pyrimidin-4-one) and/or 2, 2-(1,4-Phenylene)-bis-(thieno [2,3-d] pyrimidin-4 (1H)-one) Derivatives. Zeitschrift für Naturforschung B, 65(9), 1148-1154. DOI:
  10. Singh, P., Bisetty, K., & Mahajan, M. P. (2009). Alternative synthesis of 2,4-substituted-1,3-thiazines and 2,5-substituted-thiazole derivatives South African Journal of Chemistry, 62, 156-162.
  11. Usharani, P., & Madhavi, N. (2019). Zinc oxide nanoparticles as facile catalysts for the rapid synthesis of 5-methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)-1-arylethyl)-1 h-pyrazol-3-ols in aqueous media catalyst, 12(4), 2023-2029. DOI: